Avandia product group sales declined 38% to 225 million Sales of the Avandia product group, for the treatment of type 2 diabetes, fell 38% to 225 million for the quarter, with US sales down 48% to 130 million. Sales in European and International markets declined 11% to 50 million and 22% to 45 million respectively. On 30th July, an FDA Advisory Committee met to discuss the potential cardiovascular risks associated with the use of thiazolidinediones, with a specific focus on Avandia. The FDA is currently reviewing the committee's recommendations. Lamictal, Valtrex and Requip combined sales grew 16% to over 550 million Sales of Lamictal, for the treatment of epilepsy and bipolar disorder, grew 14% to 275 million, with strong sales performance in the USA, up 20% to 224 million. In September, GSK received an FDA approvable letter for Lamictal XR, a once-daily extended-release treatment for epilepsy. The company is discussing with the FDA the next steps for the application. Sales of Valtrex, for herpes, rose 13% to 229 million, with US sales up 11% to 162 million. Sales of Requip, for Parkinson's disease and restless legs syndrome RLS ; , grew 31% to 87 million in the quarter, driven by strong sales in the USA, up 39% to 59 million. In August, GSK received an approvable letter for Requip 14hr for treatment of RLS. A decision from the FDA on the marketing application for Requip 24hr for Parkinson's disease is expected in December. Other key growth drivers contribute 154 million of sales in third quarter: Avodart, for enlarged prostate, continued to perform strongly with sales up 33% to 72 million. During the quarter, GSK announced new results from the CombAT study combination therapy with Avodart and tamsulosin. These data, which have been submitted to regulators, showed that Avodart and tamsulosin in combination provide significantly greater urinary symptom improvement for men with enlarged prostate than either treatment used as monotherapy. GSK's share of the co-promotion income for Boniva Bonviva, the only once-monthly medicine for postmenopausal osteoporosis, was up 56% to 41 million. Sales of Arixtra, a once-daily anticoagulant, doubled to 25 million. During the quarter Arixtra was also approved in Europe for the treatment of acute coronary syndromes. Sales of Tykerb, for breast cancer, were 16 million in the quarter with the product continuing to gain share of the Her2 + metastatic breast cancer market. Other products Total sales of HIV products were 360 million, up 3%, with strong sales growth from new products Epzicom Kivexa + 33% to 80 million ; and Lexiva + 19% to 37 million ; offsetting competition to older products, Combivir -4% to 115 million ; and Epivir -13% to 38 million ; . Sales of Relenza, GSK's anti-viral for influenza, were 28 million, down 7%, reflecting lower demand from governments to stockpile it for use in the event of a flu pandemic. Sales of Zofran -86% to 32 million ; , Flixonase Fl9nase -23% to 49 million ; and Wellbutrin XL -41% to 114 million ; decreased as a result of generic competition to these products. Total sales of Coreg IR and Coreg CR, for heart conditions, were 145 million, down 20%, reflecting generic competition to Coreg IR which began in September. Sales of Coreg CR were 31 million during the quarter. Intranasal corticosteriods are very effective as flonase fluticasone propionate.

Food bank's effort to feed lower-income children. As you may have read in the local papers, times are tough for food banks. There is a particular need for nutritious food for children, which is provided in weekend food bags to kids whose families are living in poverty. Their wish list includes canned fruit, juice boxes, peanut butter, jelly, granola bars, cereal, macaroni and cheese, or items such as canned spaghetti. Just before Purim, our Chag Sameah program returns to Chevy Chase Retirement Home to visit seniors. On March 16, we will gather at the synagogue at 10: 30 a.m. and join students in a short learning session to prepare for our visit. A bus will take us to and from our 11 a.m.12 noon program. If you are interested in participating, please email rabbi.winaker adasisrael . Finally, Sukkot in April is coming up.well, in April. Anxious for an outlet to display your home improvement skills? Have a hankering to spend a day painting? We can use your help to repair the home of a lower-income family in the District. Watch for more details in the next Chronicle and decadron.
A warm welcome to all of our members. The Society for Male Reproduction and Urology continues to provide information regarding Male Reproduction and Andrology for physicians, scientists, other health care providers, as well as the public. We accomplish this through our website and during the annual ASRM meeting. Members of our society include a diverse group consisting of urologists, medical and pediatric endocrinologists, reproductive endocrine and infertility specialists, basic scientists, nurses and laboratory scientists. Our postgraduate courses and symposia at the annual meeting are designed to appeal to all members of the ASRM. The 2008 Postgraduate Course is, "Unraveling the Mysteries of Spermatogenesis: Contemporary Therapies, Stem Cells, and Beyond" chaired by Robert E. Brannigan, M.D. By attending this course, we hope to broaden the attendees' understanding of spermatogenesis and the variety of contemporary therapies available to address specific spermatogenic disorders. We also aim to provide attendees with a state of the art overview of important, emerging technologies such as germ cell transplantation and stem cell based therapy for male infertility. By the end of the course, the attendees should be able to describe the pathophysiology associated with both congenital and acquired disorders of spermatogenesis, discuss investigational and emerging technologies for the treatment of male infertility including germ cell transplantation and stem cell based therapy, as well as review contemporary methods to preserve and restore fertility in male cancer patients. We will also be co-sponsoring an interactive session, along with the Environment and Reproduction Special Interest Group ERSIG ; entitled, "Male Reproductive Toxicology" with Drs. Susan Benoff and Mark Sigman, three mini-symposia: Gabor Huszar M.D. Yale ; : "Sperm Biochemical Markers and Their Relationship to Sperm Morphology", Darius Paduch, M.D., Ph.D Cornell ; : "Klinefelter's Syndrome: Novel Scientific and Clinical Insights", and Gail Prins, Ph.D UIC ; : "The Reproductive Aspects of the Prostate: Growth, Development, Function, and Impairment", as well as our three concurrent scientific sessions. As part of our educational outreach program, the SMRU continues to support the Annual SMRU Traveling Scholars Award Program. The objective of this program is to expose residents, fellows, Ph.D students, and post-docs to new scientific information per continued on page 2.
This list is a brief summary and not a complete list of medications covered A&B Otic Dilantin Opti-Pranolol Abilify Ditropan XL Oramorph SR Accolate Dovonex Pentasa Accu-Chek Comf. Curve Dynabac Phenergan Suppositories Accutane E.E.S. PHisoHex Acetasol HC Effexor XR Plavix Actonel Efudex Povidine Iodine Soap Adderall Generics & Adderall XR Emend DoD quantity limits apply ; Pred Forte 5ml only ; Advair Epi-Pen Premarin Aggrenox Ery-Tab Premarin Vaginal Cream Alomide Eskalith Prempro Alphagan P & Brimonidine Alphagan Gen ; Est-Ring Prenavite Ambien not Ambien CR ; Evista Primidone Androderm patches Flonse Prometrium Antabuse Florinef Proscar Aricept Flovent HFA Pulmicort Flexhaler Armour Thyroid Floxin Otic Drops Pulmicort Nebulizer Asacol Geocillin QVar Astelin Nasal Spray Geodon Reminyl Atrovent HFA Glucogon Kit Requip Atrovent Nasal Glucophage XR Risperdal Risperdal M requires PA ; Augmentin Suspension Glucotrol XL Ritalin LA Avandamet Grifulvin V Rowasa Avandaryl Gris-PEG Serevent Diskus Avandia Imitrex max 9 30 days ; Seroquel Avelox Isopto Homatropine Sinemet CR Avita Isopto Hyoscine Singulair Aygestin Kytril max 8 tabs per 30 days ; Spriva Lantus Stalevo Azilect Azmacort Levaquin Synthroid Bactroban cream oint is generic ; Levitra Tapazole Bellamine S Levothroid Tequin Betoptic S Levoxyl Tobradex Cafergot Lindane Tobrex Ointment Canasa Lithobid Toprol XL CHFonly ; Carafate Suspension Livostin Tricor Casodex Lovenox Trusopt Catapres Patches Lovolog Uniphyl 400mg only Cellcept Lumigan Urocit-K Cerumenex Menest Uroxatral Ciloxan Metadate CD Ursodiol Climara Metrogel 1% Vagifem Colestid Granules Miacalcin Valtrex Colestid Tabs Micardis & Micardis HCT Vantin Comtan Mirapex Vigamox Concerta MS Contin Viroptic Coreg please use for CHFonly ; Namenda Vytorin Cosopt Nephplex Xalatan Coumadin Nephrocaps & Nephrovites Zaditor Creon 10 Nexium Zarontin Cyclogyl Niaspan Zocor Cytomel Niferex Forte 150 Zoloft 1 2 tabs ; Depakote & Depakene NitroDur patches Zomig max 8 30 days ; Depo-Testosterone Nizoral Shampoo Zonolon Detrol LA not regular Detrol ; Novolin Zovirax Ointment Didronel Ocuflox Zymar Diflucan Omeprazole Zyprexa and rhinocort. The etrog should have the shape of a tower, narrower at the top and wider near the stem. The area around and below the tip pitom ; should be free of spots and blemishes. Potential uses include. Detection of heart disease Mitral valve disease Dilated cardiomyopathy Severity, prognosis, response to treatment, and cause of respiratory distress and serevent!

The requirements respecting information and records set out in section C.05.012 are met; and j ; the drug is manufactured, handled and stored in accordance with the applicable good manufacturing practices referred to in Divisions 2 to 4 except sections C.02.019, C.02.025 and C.02.026. 392 patients independently completed the hospital anxiety depression scale HAD; Zigmond and Snaith 1983 ; and the Leeds sleep evaluation questionnaire Parrott and Hindmarch 1978 ; . Signs and symptoms elicited by patient interview and investigator observation were recorded as adverse events at baseline and at each follow-up visit. No laboratory tests were performed. Global evaluations of efficacy and tolerability were made at week 8 or upon unscheduled patient discontinuation. Body weight was recorded at screening and on all subsequent visits. Statistical methods The primary efficacy analysis was performed on an intention-totreat ITT ; basis, including all patients who had at least one postrandomized efficacy assessment. The group examined for medication tolerability had at least one assessment after receiving the drug in a double-blind fashion. In the evaluation of study center effects, a study center was defined as one that produced at least five ITT patients per doubleblind treatment. Centers with fewer than five patients were pooled, resulting in a final set of six centers for analysis. Chi-square tests were used to evaluate homogeneity between the treatment groups for patient characteristics recorded at screening and the distribution of patient enrollment. Analysis of variance ANOVA ; including treatment, center and treatment by center interaction items was used for testing the homogeneity of efficacy variables measured at baseline. The differences between treatment group of the efficacy data at each visit observed values ; and endpoint last observation carried forward ; were tested using analysis of covariance ANCOVA ; including treatment, center, and their interaction as the main effects, baseline as the covariate for the mean change from baseline values. The 95% student t confidence limits were performed for the primary efficacy analysis. The proportions of patients achieving a 50% or greater reduction in 29-item HAMD scores from baseline in the active treatment and placebo groups were compared using Fisher's exact test. Also, the proportion of subjects in each group achieving a score of one or two on the CGI-I ratings indicative of much improved or very much improved clinical status relative to assessment at screening ; were compared, also using a Fisher's exact test. The incidence of treatment-related adverse events were summarized for each treatment group using the World Health Organization body-organ system. Fisher's exact test was used to compare the proportions experiencing adverse events in the two study groups. All P values reported reflect two-sided significance tests and aristocort. Absolute risk is low. The editorial also notes that the results are consistent with the growing body of literature on the effects of combination oestrogen progesterone. Editors note: 3 The Committee for Safety of Medicines considered a pre-publication copy of this study and note that the absolute risks from HRT were small and that the overall rates of deaths and all cancers were not increased with combined HRT. They also raise the following points: The results of the WHI study confirm what is already known about the long-term risks of HRT including risks relative to breast cancer and venous thromboembolism Combination HRT is only indicated for treatment of menopausal symptoms and prevention of osteoporosis HRT has not been proven to be beneficial in preventing CHD and may result in a small increased rate of CHD The results do not necessitate any immediate changes in treatment Women on HRT should have health regularly reviewed and be encouraged to have mammography and cervical screening as appropriate The US preparation used in this study was Prempro. There is a similar preparation available in the UK, Premique conjugated equine oestrogen 0.625mg + 5mg medroxyprogesterone.
22. Schwetz BA, Nitschke KD, Staples RE. Cleft palates in CF1 mice after deprivation of water during pregnancy. Toxicol Appl Pharmacol 1977. 40: 307-315 and beconase. The science of treating and preventing HIV infection is evolving. In Hong Kong, a coordinated effort is needed to track the local epidemiology of HIV infection in women, use of prophylactic measures against perinatal transmission, and outcome of such treatment. This knowledge base will be useful in formulating strategies toward preventing this disease in children. Nasal Corticosteroids These agents have been shown to have equivalent efficiency. Aqueous AQ ; forms may be less irritating. Nasonex can be used in children as young as 2 years. Nasonex and Flonase have low systemic biovavailability. Added to PDL: flunisolide generic ; , Flonase, Nasonex and deltasone.

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